How is a probe used

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Join Us! Atomic force microscopy is applied to image the location of chemical groups inside single protein complexes. Research Highlights 05 November Two studies report the design of DNA hairpins that function as optical probes of cellular traction forces, offering high spatiotemporal resolution and signal-to-noise ratio.

Advanced search. Skip to main content Thank you for visiting nature. Stawicki , Torri E. Protocols 28 July Regional and functional division of functional elements of solid-state nanochannels for enhanced sensitivity and specificity of biosensing in complex matrices This protocol enables explicit regional and functional division of functional elements of solid-state nanochannels to improve the sensitivity and specificity of bioanalysis in complex matrices.

Nature Protocols 16 , Nature Biomedical Engineering 4 , Research 23 March Open Access Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids Size-selective discrimination is an issue in biosensing. Nature Communications 11 , Nature Methods 18 , Research Highlights 17 May I spy in my nuclei This study identifies a human antibody fragment that recognizes i-motifs and shows that these DNA structures are present in the nuclei of human cells.

Nature Reviews Chemistry 2 , The labeled DNA can be used as a probe in a blot hybridization experiment. Labeled DNA can be located on a blot by using antibodies against digoxigenine. The digoxygenin group is the label used in the Southern hybridisation step in the Simple Cloning Lab. Below, the molecular structure of Dig-dUTP is shown. So, highly antigenic digoxigenin will be present in the new DNA. Digoxigenin can be detected by antibodies , conjugated to the enzyme Alkaline Phosphatase.